Gerbode defects are a very rare anomalies, characterized by direct communication between left ventricle (LV) and right atrium (RA). Most defects are congenital, but they can also be acquired following destructive heart diseases, such as infective endocarditis, myocardial infarction, trauma, or cardiac surgery. In this paper, we report the case of a 35 years-old patient hospitalized for management of an infective endocarditis complicated by a Gerbode defect.