The objective of this study was to determine the level of contamination of chicken meat and eggs collected from poultry farms in Ivory Coast by antibiotics (sulfadiazine, sulfadimethoxine, sarafloxacin and oxytetracycline). To carry out this work, thirty (30) samples of chicken flesh and thirty-six (36) samples of eggs were collected on the two sites (Abidjan point kilometer 17 and Agnibilékrou). These samples were processed and then assayed on a SHIMADZU chromatographic system consisting of a sample changer, a high pressure binary HPLC pump and a UV-Visible absorption detector. The results of the analyses showed the presence of antibiotics in the chicken meat collected in Abidjan and Agnibilékrou with variable levels. In Abidjan, apart from sarafloxacin, the levels of the other antibiotics detected in the chicken meat were above the European Union standards. In Agnibilékrou, they are all outside the standards except for oxytetracycline. Regarding egg samples, the results showed the presence of only one antibiotic molecule (sulfadiazine) in egg samples taken in Abidjan and Agnibilékrou with levels below the standard set by the European Union.