Aim: overviewing the industrial ecosystem of openly available COVID-19 data, its enablers and users as well as the core value chain provided by the BeYond-COVID (BY-COVID) project. BeYond-COVID (BY-COVID) aims to provide comprehensive open data and analysis tools on SARS-CoV-2, and other infectious diseases across scientific, medical, public health and policy domains. The project has a strong emphasis on mobilising raw viral sequences, helping to identify and monitor the spread of SARS-CoV-2 variants. It further accelerates access to and linking of data and metadata on SARS-CoV-2 and COVID-19 (e.g., public health data, data on patient outcomes), enables federated data analysis to conform with data protection regulations, and harmonisation and management of meta-data and sample- identifiers, as well as long-term cataloguing to ensure interoperability of national and global efforts.