The EGI Federation as e-Infrastructure for data-intensive science has the mission to deliver generic capabilities for high volume and high and high speed data acquisition-volume and high-speed data acquisition and pre-processing, big data assimilation into model, forecast production by different simulation models, real-time processing of data, and validation of accuracy in modelling and simulation. In this presentation we will see how adopting open science practices in scientific computing at international scale enabled some of the major discoveries of our century. We will present use cases and the impact generated by opening infrastructures, software and data.