Introduction: Bowel can be affected by diverse group of pathologies causing varied morphological alteration in and around the bowel. The radiological investigation of choice depends upon the availability, accessibility, affordability and the performance of the method. Methodology: It was a hospital based prospective comparative observational type of study. Study was conducted from January 01, 2020 to December 31, 2020. After applying exclusion criteria, 50 patients of any age group with bowel related symptoms and palpable abdominal mass,which were attending & referred to RNT Medical College and Associated Group of Hospitals included in the study. Ultrasonography and CT-scans were performed in every patient.The findings were observed and tabulated. Results: The gender distribution showed male predominance. Out of 50 patients, 15 patients (30%) were female and 35 patients (70%) were male with male to female ratio of 2:1. The peak age incidence was in the 21-30 years of age group with 12 patients (24%) falling in this age group followed by 41-50 years group. There were total of 36 benign bowel wall lesions and 14 malignant cases of bowel wall thickening. Adenocarcinoma was the commonest malignant cause of bowel wall thickening constituting 11 (22%) cases out of total 50 cases, while in benign cases it was abdominal Kochs in 18 (36%) cases out total 50 cases. Conclusion: USG is often the first imaging study performed in patients with symptoms related to the gastrointestinal tract and it less invasive, more comfortable for the patient and has a good diagnostic accuracy. For indeterminate cases in USG, CT should be considered for more specific diagnosis. Over all, agreement with final specific diagnosis and diagnostic accuracy of CT for benign and malignant bowel lesions was higher than USG.