This repository holds the mass spectrometry raw data, MobiDB-lite search data, FIMO motif instances for all tiles, sequences used to make the AA sequence logos and sequence conservation data for Drosophila and human transcription-related proteins. Mass spectrometry raw data files for two runs containing different samples: IP-MS1_raw.xlsm and IP-MS1_raw.xlsm MobiDB-lite search (from interpro scanning) for entire Drosophila melanogaster proteome (used to compare % of IDRs): MobiDBLite_twist007_CDs_pep.tsv Motif scanning with FIMO for all tiles used to distinguish motif versus non-motif tiles: Motifs_FIMO_all_tiles.tar.gz Sequences used to make the AA sequence logos in Suppl Fig 6B: Sequences_for_AA_logos.tar.gz Conservation analyses files: Drosophila_human_motif_instances_FIMO.tar.gz Instances of each peptide motif in all Drosophila and human proteins mapped by FIMO DrosophilaMelanogaster_orthogroups.tar.gz *aacon.UniProtID.aacon files contain the sequence conservation scores for the Dosophila transcription-related proteins twist_library_CDs_pep.fa.mapped_peps.fa Protein sequences of the insect transcription factor database mapped to UniProt twist_library_CDs_pep.fa.mapping.tsv Annotation and orthogroups of the Dosophila transcription factor database Dmel_motif_cons_table_AA.txt Conservation per position (core and flanks) for each motif instance in Drosophila proteins (Data for Suppl Fig 5) HomoSapiens_orthogroups.tar.gz *aacon.UniProtID.aacon files contain the sequence conservation scores for the human transcription-related proteins human_TFs_and_tx-related_proteins.tsv.mapped_peps.fa Protein sequences of the human transcription factor database mapped to UniProt human_TFs_and_tx-related_proteins.tsv.mapping.tsv Annotation and orthogroups of the human transcription factor database