ABSTRACT Objective: This research set out to compare the ability of roots obturated with two different kinds of endodontic sealers.; Endo sequence bio ceramic and epoxy resin sealers to withstand vertical force. Methods: Thirty teeth with just one root were prepared and separated into 3 groups (n=10). Group I filled the root canals with protaper guttapercha\ Endo sequence bio ceramic sealer, group II filled the root canals with protaper guttapercha \epoxy resin sealer: group III (control) canals were prepared only and left without obturation. The withstand of roots to break was assessed with a universal testing device by measuring the greatest load in Newtons used to break each root. ANOVA test was utilized to make a data analysis, then Tukey test was utilized to decide the significance value at (P≤0.05). Results: Endo sequence bio ceramic sealer group exhibited slightly better withstand to fracture than epoxy resin sealer group. while the experimental group and the control group did not show any statistically significant differences. Conclusion: protaper guttapercha / Endo sequence bio ceramic sealer reinforces the root canal more than protaper gutta-percha /epoxy resin sealer.