ABSTRACT Cubosomes are square and adjusted particles with inner cubic cross section. Cubosomes are thermodynamically steady and comprise of honeycombed (enormous) structures isolating two inward watery channels and a huge interfacial region. Cubosomes are nanoparticles which are self gathered fluid translucent particles of specific surfactants with appropriate proportion of water with microstructure that gives extraordinary properties of commonsense interest. Bicontinuous cubic fluid glasslike stage is optically clear and extremely thick material has the special design at nanometer scale. The word bicontinuous alludes to the division of the two ceaseless however non-meeting fluid areas by lipid bilayer that is wound into space filling structure. Hydrating a surfactant or polar lipid that structures cubic stage and afterward scattering a strong like stage into more modest particles generally shapes a Cubosomes. Self-gathered Cubosomes as dynamic medication conveyance frameworks are getting increasingly more consideration and interest after the primary revelation and assignment. They show different inward cubic design and creation with various medication stacking modalities. It has high inward surface region and cubic translucent designs, somewhat basic planning strategy, biodegradability of lipids, the capacity of typifying hydrophobic, hydrophilic and amphiphilic substances, focusing on and controlled arrival of bioactive specialists. Cubosomes are having wide scope of uses in different fields and they can be described by different assessment boundaries. Along these lines, Cubosomes are acquiring consideration in drug field. Keywords: Cubosomes, Liquid crystal, drug-loading, hydrophilic, hydrophobic, amphiphilic