To evaluate the effectiveness of Pranayama on fatigue among women with breast cancer receiving chemotherapy in a selected hospital at Coimbatore. Methods: The studies design adopted become quasi experimental non-equal manage institution pre-test publish-test design. The conceptual framework for this examine changed into based on Imogene King’s goal Attainment idea (1981). The observe became carried out in GKNM health facility at Coimbatore in 2012. Non-possibility purposive sampling approach become followed to pick out the preferred sample. The pattern size became 60. As an intervention, 30 minutes of Pranayama for 5 days became validated for Experimental group. The information changed into gathered thru Schwartz cancer Fatigue Scale. There have been 30 individuals in every group (manage institution and Experimental organization). The accumulated information have been analyzed by way of the use of both Descriptive and Inferential Statistical techniques. ‘t’ take a look at changed into used to assess the effectiveness of Pranayama on fatigue among girls with breast cancer receiving chemotherapy. Findings: With reference to effectiveness of Pranayama on fatigue amongst ladies with breast cancer receiving chemotherapy, the imply post-test score of fatigue was less than the imply pre-test score amongst experimental institution. The obtained ‘t’ price 15.39 became significant at P<0.001 degree. The experiment concludes that Pranayama facilitates lowering the extent of fatigue amongst ladies with Breast most cancers receiving Chemotherapy