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The Micro, Small, and Medium Enterprises (MSME) sector has grown to be a vibrant area of the Indian economy and a crucial engine of the economic cycle. It generates the second highest employment possibilities and significantly aids in the growth of entrepreneurship. The MSME sector significantly contributes to the growth of the Indian economy, accounting for more than sixty-three million three hundred eighty thousand enterprises, over forty percent of exports, over twenty-eight percent of the GDP, and providing employment for about one hundred eleven million people. In this paper, an attempt has been made to analyses the major role of the MSME sector in North East India, and a brief discussion of the current situation, employment status, an overview of the targeted activities, and the growth and distribution of MSME in North East India. To achieve the study's various objectives, various methodologies were used. Secondary data has been analyzed to investigate the significant role of the MSMEs sector in North East India. According to the findings and analyses, the MSMEs sector as a whole is the engine of growth for the Indian economy and North Eastern states development. According to the study, there is an increasing pattern in the number of units, employment, and asset market value. It is worth noting that there is a strong relationship between the total factory unit and employment. The role of the MSMEs sector is rapidly expanding, and it has become a focal point for future growth in rural and urban development, with significant policy implications.