This repository contains five supplementary data files for the research article "Reduced B-cell antigenicity of Omicron lowers host serologic response". For more information, please refer to the article preprint https://doi.org/10.1101/2022.02.15.480546 and upcoming article at Cell Reports. Table_hCoV229E.xlsx: list of hCoV229E RBD sequences, with associated isolate and collection date identifiers, and ScanNet antigenicity score for reproducing Figure 3A. Aligned sequences and templates are also provided. table_artificial_variants.csv: List of artificial RBD sequences generated by an evolutionary-based sequence generative model for reproducing Figure 3B, Supplementary Figure S6H. MSA_RBD.fasta: Multiple Sequence Alignment of RBD sequences and sample weights used for training the sequence generative model used in Figure 3B, Supplementary Figures S2C, S6. table_antibody_hit_rate_RBD.csv: Empirical epitope distribution for the RBD, as determined from the Protein Data Bank and raw data for Supplementary Figure S1). RBD_virtual_DMS.xlsx: virtual Deep Mutational Scan performed with ScanNet and the sequence generative model shown in Supplementary Figure S2.