We conducted this study, titled "Methicillin-Resistant Staphylococcus aurous and its Determinants of Raw Cow Milk Contamination in a Selected Gamo Zone District of Southern Ethiopia," in order to disseminate our findings to the scientific community. The research has its own strengths, such as the work we did on milk quality and potential milk borne pathogens, as well as the determinants of contamination at the selling point, which is only on fresh milk after it has been checked for freshness. As a result, the authors initiated this research based on practical challenges encountered while providing professional support to various producers in the milk selling point. Because of the irrational use of antibiotics among human and animal health in the study area, this research aimed to estimate the microbial load, prevalence of methicillin resistant S. aurous (MRSA), and determinants of raw cow milk contamination at selling points. This could be a source of drug resistance development in Ethiopia and in the study area in particular. Furthermore, due to resource constraints, the study focuses on bacteriological analysis, risk factor association, and drug sensitivity testing, which can serve as baseline data for future characterization and intervention. Hoping that we authors are interested to publish our research output in your journal with your eminent support for the article gets published.