This document was developed to provide a standard operating procedure (SOP) on clinical (secondary use) and preclinical in vivo data acquisition in order to create virtual cohorts for in-silico modelling. Considering the different requirements and processes involved in the acquisition of clinical vs. preclinical data, the document is split into 2 parts. Additionally, the SOP is designed for SIMCor partners as well as for the overall scientific community. Different countries and local organisations follow several different regulations and procedures for the acquisition and processing of data for research purposes. Therefore, this SOP provides general recommendations and comments, along with specific examples related to the SIMCor use cases: transcatheter aortic valve implantation (TAVI) for clinical data acquired at University College London (UCL) and Charité (CHA), and pulmonary artery pressure sensors (PAPS) for preclinical data acquisition.

SIMCor (In-Silico testing and validation of Cardiovascular IMplantable devices) has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 101017578.