(A) Architecture of macaque TB lung granuloma, where lymphocytes and macrophages are present in distinct regions. Immunohistochemistry and confocal microscopy were performed on a granuloma from an animal at 11 weeks post-Mtb infection to visualize localization of CD11c+ macrophages (cyan), CD3+ T cells (yellow), and CD20+ B cells (magenta) (B) Detection of mast cells in a 10-week NHP granuloma using immunohistochemistry, staining for tryptase (green) and c-kit (CD117)(red). (C) Detection of mast cells in a human lung granuloma. Hematoxylin and eosin stain and immunohistochemistry with multinucleated giant cells (stars, (top left) and c-kit (CD117) staining (indicated by arrows, top and bottom right).

{"references": ["Gideon, Hannah et al. (2022). Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control"]}