Objective: To find out prevalence of dyslipidemia, vitamin B12 deficiency and depression in hypothyroid patients. Methodology:A cross sectional observational study was carried out in 2 hospitals to estimate the prevalence of dyslipidemia, vitamin B12 deficiency and depression in 60 patients of hypothyroidism. Data of demographic details, past medical history, current ongoing major illness, medications and past laboratory reports was collected from case record file of patients. Results:Out of 60 hypothyroid patients, 90% of the patients were females and 10 % were males. The prevalence of hypothyroidism was highest in the age group of 31-40 (45 %) followed by the age group of 41-50 (35%). According to BMI interpretation, 65 % of the patients were overweight. Out of 60 patients, 47 (78.3 %) patients had established hypothyroidism and 13 (21.7%) patients were newly diagnosed. Out of 13 newly diagnosed patients, 6 (10.3 %) had subclinical hypothyroidism and 7 (11.7%) had overt hypothyroidism.Percentage of patients with dyslipidemia, vitamin B12 deficiency and depression were 25, 16.7 and 10 respectively. Conclusion:The prevalence of hypothyroidism was higher in patients having age of 31 to 40 years. Majority of the patients were females. Percentage of patients with established hypothyroidism were more than newly diagnosed patients. Majority of the patients were overweight. Prevalence of dyslipidemia was highest among hypothyroid patients followed by vitamin B12 deficiency and depression.