In this deliverable we report on efforts of EATRIS-Plus sites in the certification of pre-analytical sample processing and in the development of reference values and material for omics technologies used to generate the multiomics data in WP1. The technical validity of an experimental process, the quality of the resulting data and reproducibility of the results can be assessed by comparing the data to a known range of values that were developed from well-characterized samples and controlled experimental conditions. Since the experimental processes can differ widely, it is useful to develop target ranges of detection, that are applicable to most commonly used technologies. The development of reference material and the use of target value ranges is discussed in principle and in examples.