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Article . 2022
License: CC BY
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Radiotherapy Biological Tumor Control Probability Integral Equation Improved Model with Analytic Determination

Authors: Francisco Casesnoves;

Radiotherapy Biological Tumor Control Probability Integral Equation Improved Model with Analytic Determination

Abstract

Th e research objective was to obtain a fast/simple analytic solution for previously published Radiotherapy Tumor Control Probability (TCP) Integral Model by other authors . Finding, firstly, is a new/simpler Probability Function than Poisson distribution of survival clonogens which is developed from classical biological model algebraic/numerically modified equation. Solution obtained is t his Probability Function alternative based on a Binomial distribution equation approximation from literature. Result, t hus, is its use of for developing a fast/analytic solution of the 2D [ α and β biological modelling parameters ] Integral Model Cumulative TCP. The Gaussian Normal distribution convolution is implemented with th is P robability F unction into the integral model to sort longer/programming numerical methods and determine an analyt ical solution expression. As a complete result, a formulation for TCP based on Erf functions is obtained. Applications for radiotherapy treatment planning optimization improvements with biological models are explained.

Keywords

Mathematical Methods (MM ) , Biological Models (BM), Clonogenes Population Survival Rate, (SR), Integral Equation (IE), Tumor Control Probability (TCP) , Radiation Photon - Dose (RD) , N onlinear Optimization, Integral Approximations , Anisotropic Analytic Model ( AAA ) , Radiotherapy Trea tment Planning Optimization (TPO)., Mathematical Methods (MM ) , Biological Models (BM), Clonogenes Population Survival Rate, (SR), Integral Equation (IE), Tumor Control Probability (TCP) , Radiation Photon - Dose (RD) , N onlinear Optimization, Integral Approximations , Anisotropic Analytic Model ( AAA ) , Radiotherapy Trea tment Planning Optimization (TPO).

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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