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In this study, we compared the antioxidant activity, cytotoxicity, and antiviral activity of ten common phenolic acids and flavonoids which naturally occurred in many plants and byproducts sources. Antioxidant activity was analyzed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azinobis (3 ethylbenzothiazoline-6-sulfonic acids) (ABTS) radical-scavenging activity, while cytotoxicity and antiviral effects of the polyphenols were evaluated using MDCK cells line model. The results showed that different phenolic acids and flavonoids showed a significant difference in antioxidant activities as well as cytotoxicity. Amongst tested compounds, pyrogallol and catechin showed higher DPPH radical scavenging ability, while ellagic acid and quercetin had the higher ability for ABTS assay. Furthermore, our results indicated that the antiviral activity potential varied significantly among polyphenols, and that several compounds including gallic acid, quercetin, rutin and vanillic acid have potent antiviral activity against the influenza A virus.