Quality of life (QoL) is an important goal that needs to be achieved by an urban society in general and a neighborhood in particular. The physical space and the QoL of a community are related to a very significant extent. Physical space provides a setting for community living among the residents. There is a sense of place attachment through the way people interact and engage with the physical space. This sense of space becomes even more important in the present context, because of the rapid process of urbanization, which has negatively impacted the QoL in Urban areas. This paper attempts to identify the connection between urban design parameters and Quality of life (QoL) through a literature survey. The attempt is to review various definitions and dimensions of QoL as discussed in the contemporary urban design theories and approaches, both objective and subjective. Furthermore, this paper discusses methods put forward by various researchers to quantify the qualitative aspects of QoL. Finally, a matrix is proposed to establish a set of parameters that includes physical, social, environmental, and psychological concerns of Quality of life in urban neighborhoods. These parameters may act as a guide for the analysis of the urban neighborhoods from the perspective of Quality of Life (QoL)