Abstract: Background: Endotracheal intubation is routinely practiced in general anesthesia, with potential hemodynamic effects on patients. Several techniques and adjuvants have been tried to improve intubating condition, like potent volatile agents, opioids, lidocaine, B-blockers and MgSO4 or combination of more than one technique. Objective: To assess the profile effect of the use of MgSo4 to attenuate hemodynamic response to tracheal intubation. Patient and methods: A prospective randomized double blind clinical trial study of 40 patients undergone elective lower abdominal and perianal surgeries, 20 of them received Mg sulfate 30 mg / kg before the induction, the other 20 received normal saline, vital signs (pulse rate and rhythm, systolic and diastolic blood pressure) were recorded after mg sulfate, pre induction, pre intubation, directly after intubation and 3 min. after intubation. Results: It was found there were significant differences between both groups in vital signs after mgSO4 administration, were p – value below 0.05. Group A (magnesium sulfate) shows significant prolongation in a time from reversal of muscle relaxant and Extubation were the p – value below 0.05. There were no significant differences between (magnesium sulfate) and (control group) in the duration of operation, intubation score, and incidence of dysrhythmia. VIII. In addition, there was no significant differences in Vital Signs at preoperative reading and after 3 min. after intubation were the p – value above 0.05. Conclusion: The use of I.V. magnesium sulfate is an effective technique in reducing the hemodynamic response to laryngoscopy and tracheal intubation with prolongation in the time of recovery.

Salman I A, Jaleel O K, Humood M S, The Profile Effect of the Use of MgSo4 to Attenuate Hemodynamic Response to Tracheal Intubation, JMSP 2022, 8(3): 112-30. DOI: 10.5281/zenodo.6886989