In the school year 2020-2021, INDIRE launched in Italian small schools a pilot experimentation of a teaching method already validated in Québec and considered useful for overcoming the educational limits typical of remoteness scenarios (Mangione and Cannella, 2020). “Classi in rete” is characterized by a shared didactic practice where “delocalized” classes are involved in a common disciplinary path by adapting calendars, spaces, and teacher roles, using virtual twinning environments, videoconferencing and spaces for discussion such as the Knowledge Forum (KF) (Mangione and Pieri 2019; Mangione et al., 2021). The experimentation of the model in Abruzzo involved 12 small schools and is based on a design-based research methodological approach (Sandoval, 2014). This paper aims to answer the following questions: Q1 Has the experience of networked classes fostered changes in the teaching practices and strategies of teachers? Q2 Which are the elements that conditioned the teamwork in open classes? The analysis uses a mixed method that integrates a standard search through data matrix and an interpretative search through group interviews aimed at the involved teachers and students. In fact, alongside a structured quantitative survey aimed at understanding the impact that the model had in the experimental classes in terms of collaboration, interdisciplinarity, reorganization of times and workspaces, we conducted a qualitative analysis based on focus groups with the teachers involved aimed at understanding to what extent the model has affected their propensity for change.