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Article . 2022
License: CC BY
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Article . 2022
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Structural features affecting the selectivity of LAT1-targeted phenylalanine drug conjugates

descriptionPublicationkeyboard_double_arrow_right Article 15 Jul 2022Publisher:Zenodo
Authors: Katayun Bahrami; Järvinen, Juulia; Laitinen, Tuomo; Reinisalo, Mika; Honkakoski, Paavo; Poso, Antti; Huttunen, Kristiina M.; +1 Authors

doi: 10.5281/zenodo.6841458 , 10.5281/zenodo.6841457

Structural features affecting the selectivity of LAT1-targeted phenylalanine drug conjugates

Abstract

This file contains favorable docking poses of a series of compounds to the Large neutral Amino acid Transporter 1 (LAT1). The compounds were docked to the cryo-electron microscopy structure of LAT1 (Protein Data Bank ID: 6IRT). The data have been generated by induced-fit docking using the Schrödinger maestro suite 2021-04. For data visualization, Schrödinger maestro suite 2022-02 was utilized.

Other foundations which support our research include: Orion Research Foundation, and The Finnish Pharmaceutical Society.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green