Aim: This review article focusses on the availability of drugs and their use in Endodontics. Background: This study aimed at reviewing the use of analgesics, antibiotics and their use in Endodontics, in form of oral or its application. Dosage and inappropriate use of drugs was added into this review. Methods: The systematic literature search was performed in three databases from 1993 to 2013.English articles that focused on drugs used in endodontics and their role were searched. Systematic and narrative reviews were included. Result: After evaluation of search papers, 12 relevant articles were used in this review. The importance of drugs with their role, dosage, uses are highlighted in this study. Drugs play an essential role in treatment protocol but at the same time its misuse should be avoided. Conclusion: There is availability of systemic and topical drugs but their use and dose should be assessed before administration and unnecessary use of these should be avoided.