- Hypersensitivity is the most common adverse effect of vital tooth bleaching. To overcome this, a lot of desensitising agents are introduced. casein phosphopeptide-amorphous calcium phosphate (CPPACP) is a milk- derived complex that causes demineralisation of tooth structure. To assess the efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP)in treating the hypersensitivity associated with vital tooth bleaching.A systematic review was performed using electronic databases like PubMed, science direct, Wiley online library, lilacs and google scholar using certain keywords. Out of 265 articles, five articles were related to the research topic. The review is described according to the PRISMA guidelines.CPPACP is more effective in the treatment of sensitive teeth with vital tooth bleaching. The study concludes that casein phosphopeptide-amorphous calcium phosphate complex (CPP-ACP) has the ability to reduce the postoperative sensitivity caused by at-home and in-office vital tooth bleaching without affecting the colour stability of the bleached tooth.