Introduction: Steven-Johnson syndrome (SJS) is an acute reaction that typically involves the skin and mucous membranes which are characterized by damage and flaking of the skin, accompanied by pain, and can cause death. Toxic epidermal necrolysis (TEN) is a rare, life-threatening skin reaction usually caused by medication,which is characterized by widespread erythema, necrosis, and bullous detachment of the epidermis and mucous membranes, resulting in exfoliation and possible sepsis and/or death.SJS and TEN are some of the rare side-effects from Drugs used in Anti-Tubercular Treatment.we report here a caseofSJS and TEN, due to side effects of 1st line Anti-Tubercular Drugs. Case description: A 50-year-old man presented at emergency room with chief complaints ofmultiple blisters on the trunk and erosions on the mouth and genitals for the past 4 days.He also had shortness of breath for the past 10 days, fever and cough for the past 3 days. He was apparently normal 11days back.Symptoms started appearing after initiation of Anti-Tubercular Treatment. Conclusion: As soon as the diagnosis of Anti-Tubercular Drugs induced SJS and TEN was confirmed, Patient was taken offfrom ATD and administeredwith intravenous systemic steroids as immunosuppressive therapy, antifungals, and antibiotics. After 10 days of treatment, lesions healed and started desquamating.