Dapsone a sulfonamide drug used mainly in the treatment of Leprosy and various other several bacterial infections. Rarely Dapsone can lead to hypersensitive reaction characterised by fever, yellowish sclera and other systems involved. We report a 17 year old patient presented with fever, jaundice and generalised edema with a history of borderline tuberculoid leprosy receiving Dapsone, clofizamine and Rifampicin. After confirming Dapsone Hypersensitivity Syndrome, Dapsone is stopped and treated with corticosteroids, antibiotics, Glutathione and patient recovered gradually.