The conservation of baryon number in the Standard Model stems from an empirical symmetry and does not originate from first principles. Any discovery that implies that this symmetry is broken would have far-reaching consequences for our understanding of the universe in particular the origin of the matter-antimatter asymmetry. A hypothesized process that can violate baryon number is the tri-nucleon decay, which involves three nucleons in a nucleus decaying simultaneously. In cases where the resulting daughter nucleus is unstable, the subsequent decay radiation can be searched for as evidence of the progenitor tri-nucleon decay. We discuss a search for tri-nucleon decay of ^{130}Te with CUORE using the delayed decay of expected daughter nuclei . We will present the search signature, the associated backgrounds, and the analysis techniques employed.