Background: Alopecia areata (AA) is an autoimmune disorder which is characterized with destruction of hair follicules. The disease manifests with patches of nonscarring in scalp or other hairy skin areas in varying severity clinically. The Remember/Regeneration Therapy Method (RTM) is a novel holistic medicine approach that targets physiopathological changes in quadruplet body structures, and includes various complementary methods such as acupuncture, ozone theapy and phytotherapy, etc. in different combinations which are determined depending on affected diseases. Case Report: We present a case with alopecia totalis were successfully healed with the RTM therapy without a significant side effects. Conclusion: RTM may provide consistent results for alopecia and similar many autoimmune diseases by using combinations of various holistic medicine methods in different doses, durations and sessions. The identification of epigenetically regulated genes related with autoimmune alopecia may be promising in order to develop epigenetic drugs for disease management.