Background: De Quervain Tenosynovitis was first reported in the literature in 1895 by Fritz De Quervain, describing entrapment tendinitis of the first dorsal compartment of the wrist. This study conducted to evaluate our institutions experience with De Quervain Tenosynovitis patients Methods :Retrospective cross-sectional hospital based study conducted at King Abdul-Aziz Medical City a tertiary care center in Riyadh.The study included all De Quervain Tenosynovitis cases treated in our institution between January 2008 and December 2014. Results: The study included 29 patients. Mean (Interquartile range) age was 42 (24-78) years and 19/29 (66%) were female. Mean (Interquartile range) BMI at the diagnosis was 30 (21-42). The most common radiological finding was distal radius cortical ridging17/29 (59%). Conservative treatment was initiated in 17/29 patients (59%), yet no clinical improvement noted and all the cases required surgical intervention 29/29 (100%). The intraoperative septum was observed in all cases 29/29 (100%). Conclusion: Routine wrist X-rays in DeQuervain Tenosynovitis is cost-effective and should be considered to guide the treatment course with low threshold for surgical intervention might be warranted particularly in obese female patient.