A growing number of microbial infections that used to be treatable with antibiotics, now again pose a threat to those infected. The reason for this is antimicrobial resistance (AMR): some pathogenic microbes have acquired defense mechanisms against existing antimicrobial drugs. The European antimicrobial resistance (AMR) Accelerator program comprises several projects with the shared goal of progressing the development of new medicines to treat or even prevent resistant bacterial infections in Europe and worldwide. The COMBINE project was created to coordinate the AMR Accelerator projects and provide them with the resources needed to achieve their goals. These include data management guidelines and an IT infrastructure to enable the collection, aggregation, storage, sharing and analysis of datasets generated by AMR Accelerator projects.