Osteoarthritis, a chronic inflammation joint disease, is an unmet medical need, causing moderate to severe disability in over 40 million people worldwide. Many patients struggle to carry out ordinary daily activities. Developing effective treatments for this debilitating condition is extremely challenging. The IMI APPROACH project is creating a platform comprising of data from thousands of patients and healthy people to identify groups of patients with similar profiles, assuming these subgroups would have a better chance to respond well to specific treatments. This patient stratification is supported by newly identified and validated biomarkers to measure disease progress.