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UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATIONOF TERIFLUNOMIDEIN TABLET

descriptionPublicationkeyboard_double_arrow_right Article 10 Jun 2022Publisher:Zenodo
Authors: Teriflunomide is the active metabolite of leflunomide. It is an immunomodulatory agent used in the treatment of multiple sclerosis. UV spectrophotometric method has been developed for the estimation of teriflunomide in tablets using methanol as solvent. Teriflunomide has shown λmaxat293nm.The method hasbeen validated according to ICH Q2 (R1) guidelines. Alinear responseis observed(R2=0.9995) in therange of 4-20μg/ml, with recovery (100.68%) andprecision (% RSD is 0.07).This method is simpleand suitable for routine pharmaceutical analysis.;

doi: 10.5281/zenodo.6630679 , 10.5281/zenodo.6630678

UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATIONOF TERIFLUNOMIDEIN TABLET

Abstract

Teriflunomide is the active metabolite of leflunomide. It is an immunomodulatory agent used in the treatment of multiple sclerosis. UV spectrophotometric method has been developed for the estimation of teriflunomide in tablets using methanol as solvent. Teriflunomide has shown λmaxat293nm.The method hasbeen validated according to ICH Q2 (R1) guidelines. Alinear responseis observed(R2=0.9995) in therange of 4-20μg/ml, with recovery (100.68%) andprecision (% RSD is 0.07).This method is simpleand suitable for routine pharmaceutical analysis.

Keywords

UV Method, UV Spectrophotometric, Teriflunomide.

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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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