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The ability of normal guinea-pig liver to synthesise indophenol-reducing substances In vitro and in vivo in presence of adequate concentrations of manganese has been demonstrated. A hypothesis that the inability of the guinea-pig and the primates to synthesise ascorbic acid within the body is due to insufficiency of manganese, which acts in the capacity of a co-enzyme in the tissues, has been advanced. The probability of synthesis of ascorbic acid in human being under certain suitable (generally acid) conditions has been discussed.
Demonstrated., Ascorbic acid, Synthesise
Demonstrated., Ascorbic acid, Synthesise
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