Thyrotoxic periodic paralysis (TPP) is one of the rare manifestation thyrotoxicosis. In this case report, we present a 36-year-old man, who had lower limb weakness for one day on waking up.He has no family history of thyroid or neurological problems.Any cause of thyrotoxicosis maybe sufficient to trigger attacks in susceptible patients. In order to permanently repair the problem, the underlying hyperthyroid status must be rectified.