Because genital tuberculosis is frequently asymptomatic, the disease may not manifest itself for years after the initial infection. Clinical symptoms usually appear 10 to 15 years after the initial infection. We report a case of 47 years old women with a history of right breast cancer who was suffering from post menauposicmetrorrhagia, ultrasound revealed thickening of the endometrium, and the biopsy revealed endometrial tuberculosis, Genital tuberculosis is uncommon in postmenopausal women and accounts for 1% of postmenopausal metrorrhagia. In 60-70 percent of cases, the endometrium is affected. It is difficult to explain the diseases low prevalence in this age group. The majority of authors believe that the endometrial atrophy and decreased vascularity associated with this hypoestrogenic phase provide an unfavorable environment for Mycobacterium growth. The standard treatment regimen is currently well codified and is based on daily administration of Isoniazid and Rifampicin for 6 months, followed by Pyrazinamide and Ethambutol for the first 2 months. Throughout the treatment, clinical and paraclinical monitoring is performed on a regular basis.