COVID-19 is a major health problem affects millions of people worldwide. The effect of COVID-19 infection is not only related to the cardiopulmonary insult, but rather affecting every system in the body. Many publications have reported common hepatosplenic insult during COVID-19 infection. Here we describe a case ofmultiple liver and splenic abscesses post corona virus infection in a healthy 13-years old girl, highlighting the possible explanations of her condition in the context of literature review. Background:Coronavirus disease 2019 (COVID-19) has been considered overwhelming heath crisis with reported death over 6 million people till now and over half billion confirmed cases according to WHO dashboard (1). This raises a concern that this virus might have the capability of attacking not only the respiratory system but also almost every single organ system. Patients with the virus have presented with features of acute liver injury, gastrointestinal symptoms, endocrine problems, neurological damage, and cardiovascular disease, most of them recover completely with no sequalae, and others develop short- and long-termSide effects(2,3). Recent research on COVID-19 have shown a high incidence of liver injury ranging from 14.8 to 53%, mainly indicated by elevated liver enzymes levels accompanied by slightly elevated bilirubin levels. The proportion of patients who develop liver injury in severe COVID-19 seems to be higher than in mild cases(4). SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) as its entry receptor, which is expressed in liver and bile duct cells (5,6), suggesting direct liver injury in patients with COVID-19.In contrary, isolated splenic affection usually passed unnoticed unless splenicthrombosis or infarction with superadded abscess formation occurred (7). Here we describe apostcovid multiple hepatic and splenic abscesses without previous abnormalities shortly after COVID-19 infection in otherwise healthy 13 -years girl.