The PRACE project provides continuous support for European HPC applications. One of the objectives of the PRACE-3IP Work Package 7 ‘Application Enabling and Support’ is to extend the support with a focus on key community codes that address major socio-economic challenges. This deliverable contains a report on major socio-economic challenges that are addressed with a selected set of community codes. These challenges are focused on problems that have substantial impact on our lives and environment or on areas that drive Europe’s economic competitiveness. The list of identified socio-economic challenges includes: Safe and Environmental-friendly energy production. Rational drug design. Future aircraft transportation. Sustainable food supply. ‘Big data’ management and processing. Multiscale modelling of the human cells and organs. Understanding of climate change. Natural environment protection. A set of European and other community codes has been carefully selected to address challenges in the identified areas. For each code, this Task will either enable the application to use HPC systems, or improve its performance. The application codes have been chosen with the support of the PRACE Scientific Committee, assuring the independence and quality of the selection. The process used for selection of these applications is described in the report. For each of the identified socio-economic challenges at least one enabling project has been defined, including its objectives, work scope, current state and the expected improvement of a given application or a set of applications. The objectives of these projects include code porting to selected Tier-0 architectures, tuning specific computational kernels to enable simulations at a desired scale, optimization of an application workflows and multi-application environment couplings. The enabling support of the selected codes associated with socio-economic challenges has already started. This deliverable presents an initial progress report for each application.