The focus is on the validation of the development results of project partners with the help of a fuselage mock-up built by Fraunhofer. Based on the accumulated experience, furthermore opportunities of cabin and cargo assembly automation are addressed. This project has received funding from the Clean Sky 2 Joint Undertaking (JU) under grant agreement No 945583. The JU receives support from the European Union’s Horizon 2020 research and innovation programme and the Clean Sky 2 JU members other than the Union. The results, opinions, conclusions, etc. presented in this work are those of the author(s) only and do not necessarily represent the position of the JU; the JU is not responsible for any use made of the information contained herein.