One of the ubiquitous causes of deaths are the Cardio Vascular Diseases or CVDs. The implementation of nanotechnology in the treatment of CVDs has evinced better bio-compatibility and enhanced cell interactions. This provides a strong potential for their mathematical modeling with the diseased blood vessels. In our current study we have reported various mathematical models used for the treatment of CVDs employing nanotechnology. Mathematical modeling provides a tool to comprehend the type, shape and size of the nanoparticles that can be employed as possible drug delivery systems. Mathematical models help to predict how nano-drugs have many improvements like expanded drug loading capacity and programmable pharmo-kinetic properties over the conventional drugs. The amalgamation of mathematical models with clinical data provides for designing these optimal therapies. This review encapsulates the current state of mathematical modeling approaches to treat CVDs using nanoparticle targeted drug delivery.