This study aims to assessment the Rule of early excision and graft in Major Burn Injury. A cross-sectional study was conducted in different hospitals in Baghdad, Iraq, where 70 patients were collected and distributed into two groups: patients and control, and the proportion of females were more than males, where the patients were distributed according to gender (20 male patients and 50 female patients). Where this study was conducted retrospectively, where the time of the first circumcision was linked to infection and death, and the statistical analysis program SPSS IBM SOFT 2022 and Microsoft Excel 2013 was used to analyse the data and demographic information obtained from the electronic record. The age groups were divided into four groups and included each of (from 15 years old to over 50 years old). Early excision and grafting of small burn wounds is a generally accepted treatment—early excision of burn injuries greater than 25 % total body surface area (TBSA) in adults. Early excision and grafting of small burn wounds are generally accepted treatment. Early excision of burn injuries greater than 25 % total body surface area (TBSA) in adults, however, has not been universally accepted. In this study, 70 patients whose age groups were divided into four groups and included each of (from 15 years old to over 50 years old). with greater than 30% total body surface area (TBSA)