Welcome to the second NSC Newsletter of 2022 and thank you so much once again to everyone who contributed. In the previous issue we published the closing proceedings of the completed BIORIMA Project. Following a report from NSC Working Group C on the Launch of the HotSpotScan (HSS) for Substance Emissions, this issue now introduces you to the ‘new kids on the block’—the LIFENANOHEALTH (Reducing nanoparticle exposures in industrial workplaces), and CHALLENGES (Real-time nano-CHAracterization reLatEd technologies) Projects, which have joined the NSC community. We look forward to their news and activities as they develop. We follow this with news from a number of the NSC projects which have shared their latest news, as well as links to their newsletters and videos where you can find out more. In subsequent new, find out how NanoHarmony and NANOMET have joined forces to launch a joint workshop on test guidelines at the OECD. We then hear from the LightMe initiative and the role of ISQ in assessing the exposure and risks to workers handing nms during manufacturing. This is followed by updates from our NMBP projects, including Sunshine, News from SUNSHINE, SbD4Nano, Gracious, CHARISMA, NanoExplore, SABYDOMA and HARMLESS. In the Publications section we highlight the NanoImpact Special Issue which addresses Safe(r) by Design in the Nanotechnology Sector, offering a comprehensive view of the developments made in SbD in the nanotechnology sector by the EC H2020 NanoReg2 and other projects. This issue also benefits from a focus on NanoPathology, which examines the importance of this niche area, especially in the current turbulent times, and offers links to further research into possible exposure and disease. We follow this with updates from the CUSP (European research cluster to understand the health impacts of micro- and nanoplastics) projects, including details of a one-stop shop for information about mnp initiatives. Our busy Events section closes the newsletter with announcements of imminent workshops and training events happening this month and the next. We hope you find this issue of interest – and thank you everyone for your continued support of the NSC Newsletter. Keep your articles coming and have a wonderful Spring/Summer.