This study was done to determine the maximal heart rate and blood pressure difference between Treadmill Running and Ergometer cycling. This study was undertaken in research laboratory of physiology department at Thanjavur medical college . 40 persons with the age group of 18-40 Years were taken as subjects. The subjects were recruited from Thanjavur medical college. The subjects were performed 3 discontinuous graded tests until exhaustion. In Bicycle, cycling was done for 2 mins at 60rpm. In Treadmill, initial Warm-up slowly by walking at a speed of 1.5-2 mph for 1min to 2 min. For first 2 weeks subject was asked to run at 4-8 mph for 20 minutes, 3rdweek to 12thweekfor 30 mins at 4-8 mph. Physiological variables blood pressure and maximal heart rate were measured and compared in between Ergometer Cycling and Treadmill Running.