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SYNTHESIS AND CHARACRTERIZATION OF 4 THIAZOLIDINEONE DERIVATIVES

Authors: Pandurangan Perumal; Murugesan V; Sai Ramya B; Divya reddy D; Gayathri P; Charan kumar V;

SYNTHESIS AND CHARACRTERIZATION OF 4 THIAZOLIDINEONE DERIVATIVES

Abstract

{"references": ["[1]\tStana A, Vodnar DC, Tamaian R, P\u00eern\u0103u A, Vlase L, Ionu\u021b I, Oniga O, Tiperciuc B. Design, synthesis and antifungal activity evaluation of new thiazolin-4-ones as potential lanosterol 14\u03b1- demethylase inhibitors. International journal of molecular sciences. 2017 Jan;18(1):177.", "[2]\tBarreca ML, Balzarini J, Chimirri A, Clercq ED, Luca LD, H\u00f6ltje HD, H\u00f6ltje M, Monforte AM, Monforte P, Pannecouque C, Rao A. Design, synthesis, structure\u2212 activity relationships, and molecular modeling studies of 2, 3-diaryl-1, 3-thiazolidin-4-ones as potent anti-HIV agents. Journal of medicinal chemistry. 2002 Nov 21;45(24):5410-3.", "[3]\tChopra N, Kaur K, Kaur S. Assessment of Antimicrobial, Anti-Inflammatory Activity and Docking Study of Novel 2-(Arylimino)-5-(Indole-2-Yl-Methylidene)-1, 3-Thiazolidine-4-one Derivatives.", "[4]\tMital A, Prasad Burman R, Gour R, Singh Jhamb S, Singh Gill M. Synthesis, ADME Evaluation, and In Vitro Antimycobacterial Studies of a Novel Series of 2-Thiazolylimino-5- Arylidene-4-Thiazolidinone Derivatives. Anti-Infective Agents. 2017 Apr 1;15(1):38-44.", "[5]\tSingh N, Tripathi AC, Tewari A, Kumar R, Saraf SK. Ulcerogenicity devoid novel non- steroidal anti-inflammatory agents (NSAIDS): syntheses, computational studies, and activity of 5-aryliden-2-imino-4-thiazolidinones. Medicinal Chemistry Research. 2015 May 1;24(5):1927-41. 6.Gaikwad SV, Bhake AB, Bhandarkar SE. 4-Thiazolidinone derivatives: synthesis and biological study. International Journal of Chem Sci. 2015;13(3).", "[6]\tK\u00fc\u00e7\u00fckg\u00fczel \u0130, Sat\u0131lm\u0131\u015f G, Gurukumar KR, Basu A, Tatar E, Nichols DB, Talele TT, Kaushik- Basu N. 2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase. European journal of medicinal chemistry. 2013 Nov 1;69:931-41.", "[7]\tMurugesan V, Makwana N, Suryawanshi R, Saxena R, Tripathi R, Paranjape R, Kulkarni S, Katti SB. Rational design and synthesis of novel thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic & medicinal chemistry. 2014 Jun 15;22(12):3159-70.", "[8]\tBrahmbhatt H, Molnar M, Pavi\u0107 V, Rastija V. Synthesis, Characterization, Antibacterial and Antioxidant Potency of NSubstituted- 2-Sulfanylidene-1,3-Thiazolidin-4-one Derivatives and QSAR Study. Med Chem. 2019;15", "[9]\tSolomon VR, Haq W, Srivastava K, Puri SK, Katti SB. Design and synthesis of 3-[(7-chloro-1- oxidoquinolin-4-ylamino)alkyl]-1,3-thiazolidin-4-ones as antimalarial agents. J Enzyme Inhib Med Chem. 2013;28(5)", "[10]\tD'Ascenzio M, Bizzarri B, De Monte C, et al. Design, synthesis and biological characterization of thiazolidin-4-one derivatives as promising inhibitors of Toxoplasma gondii. Eur J Med Chem. 2014;", "[11]\tCunico W, Gomes CR, Vellasco Jr WT. Chemistry and biological activities of 1, 3-thiazolidin- 4-ones. Mini-Reviews in Organic Chemistry. 2008 Nov 1;5(4):336-44.", "[12]\tIyengar DS, Kamaiah J, Aanadalwar SM, Rangappa KS, Prasad JS. Synthesis and Crystal Structure of 2-(4-Chlorophenyl)-3-(4-phthalamide)-1, 3-thiazolidin-4-one. Analytical Sciences: X-ray Structure Analysis Online. 2006;22:x181-2.", "[13]\tRB Gomes C, Moreth M, Facchinetti V, VN de Souza M, T Vellasco Junior W, Cristina da Silva Lourenco M, Cunico W. Synthesis and Antimycobacterial Activity of 2-aryl-3- (arylmethyl)-1, 3-thiazolidin-4-ones. Letters in Drug Design & Discovery. 2010 Jun 1;7(5):353-8.", "[14]\tEkinci A, Moncol J, Krishna V, Sriram D, \u00d6ZADALI-SARI K. 5-Methyl-4-thiazolidinones: Synthesis and evaluation as antitubercular agents.", "[15]\tTripathi AC, Gupta SJ, Fatima GN, Sonar PK, Verma A, Saraf SK. 4-Thiazolidinones: the advancescontinue\u2026. European Journal of Medicinal Chemistry. 2014 Jan 24;72:52-77.", "[16]\tSingh T, Khobragade D. Synthesis and evaluation of thiazolidine-4-one for their antibacterial activity. JPSBR. 2014;4:110-3.", "[17]\tRamani V, Sureja D, Patel M, Sanghvi K, Shah A, Sailor G, Seth A. Synthesis, characterization and antimicrobial activity of 2, 3-disubstituted thiazolidin-4-one derivatives.", "[18]\tKANKORIYA PK, HALVE A. Efficient Synthesis and Therapeutic Evaluation of 1, 3- Thiazolidin-4-ones as Potential Antifungal Agents."]}

Abstract: The thiazolidin-4-one core is unusually most valuable and has foreground in various clinically used medications. Most of the researchers are synthesized Thiazolidin-4-ones by using lot of conventional synthetic methods. These methods are more time consuming as well as worthful for the synthesis of compounds. Objective: Synthesis of novel substituted Thiazolidin-4-one analogues, Characterization of substituted thiazolidin-4-one analogues with chemico-spectral analysis by FT-IR, NMR and Mass spectroscopy. Method: DCC method (dicyclohexyl carbodimide). Result: Synthesized of novel substituted Thiazolidin-4-one analogues and characterized the substituted thiazolidin-4-one analogues by FT-IR, NMR and Mass spectroscopy. Conclusion: We synthesized novel thiazolidin-4-one by using conventional method like DCC method. Then the synthesized compounds were characterized by FT- IR, MASS, 1H NMR and 13C NMR. All the data of substituted Thiazolidin-4-one analogues were interpreted and tabulated. Keywords: Thiazolidin-4-one; Dicyclohexyl Carbodimide; Mass spectroscopy; NMR spectroscopy; Furan; Fourier transform Infrared spectroscopy. Title: SYNTHESIS AND CHARACRTERIZATION OF 4 THIAZOLIDINEONE DERIVATIVES Author: Pandurangan Perumal, Murugesan V, Sai Ramya B, Divya reddy D, Gayathri P, Charan kumar V International Journal of Novel Research in Life Sciences ISSN 2394-966X Vol. 9, Issue 3, May 2022 - June 2022 Page No: 10-17 Novelty Journals Website: www.noveltyjournals.com Published date: 04-May-2022 DOI: https://doi.org/10.5281/zenodo.6517058 Paper Download Link (Source): https://www.noveltyjournals.com/upload/paper/SYNTHESIS%20AND%20CHARACRTERIZATION-04052022-2.pdf

Novelty Journals, Website: www.noveltyjournals.com, International Journal of Novel Research in Life Sciences, ISSN 2394-966X

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Mass spectroscopy, NMR spectroscopy, Thiazolidin-4-one, Dicyclohexyl Carbodimide, Furan, Fourier transform Infrared spectroscopy, https://www.noveltyjournals.com/upload/paper/SYNTHESIS%20AND%20CHARACRTERIZATION-04052022-2.pdf

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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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