A d-Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway of Mycobacterium tuberculosis

descriptionPublicationkeyboard_double_arrow_right Article 11 Jan 2022 English Publisher:American Chemical Society (ACS)Journal:ACS Infectious Diseases, volume 8, pages 330-342 (issn: 2373-8227, eissn: 2373-8227,

Copyright policy )Funded by:NIH | IMPDH inhibitors for the ..., NIH | Opportunities for multi-t..., NIH | Tri-Institutional TB Rese...

Authors: Michael J. Pepi; Shibin Chacko; Gary M. Marqus; Vinayak Singh; Zhe Wang; Kyle Planck; Ryan T. Cullinane; +7 Authors

doi: 10.1021/acsinfecdis.1c00461 , 10.5281/zenodo.6512979 , 10.5281/zenodo.6512980

pmid: 35015509

pmc: PMC9558617

A d-Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway of Mycobacterium tuberculosis

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Abstract

This is the accepted manuscript version of the work published in its final form as Pepi, M. J., Chacko, S., Marqus, G. M., Singh, V., Wang, Z., Planck, K., Cullinane, R. T., Meka, P. N., Gollapalli, D. R., Ioerger, T. R., Rhee, K. Y., Cuny, G. D., Boshoff, H. I., & Hedstrom, L. (2022). A <scp>d</scp>-Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway of <i>Mycobacterium tuberculosis</i>. ACS Infectious Diseases, 8(2), 330-342. https://doi.org/10.1021/acsinfecdis.1c00461 Deposited by shareyourpaper.org and openaccessbutton.org. We've taken reasonable steps to ensure this content doesn't violate copyright. However, if you think it does you can request a takedown by emailing help@openaccessbutton.org.

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National Institute of Allergy and Infectious Diseases
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Keywords

Benzoxazoles, Phenylalanine, Coenzyme A, Mycobacterium tuberculosis, Biosynthetic Pathways

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