This is the 2022 update (first update) of the UBA list of prioritised persistent, mobile and toxic/very persistent and very mobile (PMT/vPvM) substances in the REACH registration database. All substances are registered under REACH (EC No 1907/2006) and meet the PMT/vPvM criteria as proposed by UBA in 2019. Compared to the first version from 2019, this 2022 update of the UBA list adds new substances and improved the PMT/vPvM assessment. This UBA list is published as UBA TEXTE Texte | 20/2023. It is indicated if a substance would also meet the less stringent PMT/vPvM criteria as published by the European Commission (EC) in September 2021, which was under discussion for inclusion in the Classification, Labelling and Packaging (CLP) regulation (EC No 1272/2008). Reference: Hans Peter H Arp, Sarah E Hale, Ivo Schliebner and Michael Neumann (2023). Prioritised PMT/vPvM substances in the REACH registration database, Texte | 20/2023, edited by Michael Neumann and Ivo Schliebner, IV 2.3 Chemicals, German Environment Agency (⁠UBA⁠), Dessau-Roßlau, Germany. ISBN: 1862-4804. 259 pages Acknowledgement: Environmental Research of the Federal Ministry for the Environment, Nature Conservation, Nuclear Safety and Consumer Protection (BMUV) Project No. (FKZ) 3719 65 408 0 and Report No. (UBA-FB) FB001083/ENG. Previous version: The first version of this UBA list from 2019 was published as a technical note (UBA TEXTE 126/2019). Reference: Hans Peter H Arp and Sarah E Hale (2019). REACH: Improvement of guidance and methods for the identification and assessment of PMT/vPvM substances, Texte | 126/2019, German Environment Agency (⁠UBA⁠), Dessau-Roßlau, Germany. ISBN:1862-4804, 131 pages Acknowledgement: Environmental Research of the Federal Ministry for the Environment, Nature Conservation and Nuclear Safety Project No. (FKZ) 3716 67 416 0 and Report No. FB000142/ENG. This collection is associated with list S36 UBAPMT on the NORMAN Suspect List Exchange (https://www.norman-network.com/nds/SLE/).