Introduction: Pyogenic liver abscess is aa potentially life-threatening disease with significant morbidity and mortality. Patients usually present with non-specfic symptoms initiallymaking diagnosis and treatment delayed and difficulty. Surgical drainage is associated with morbidity and mortality when compared to minimal invasive procedure and hence the study. Aims and objectives-This study was conducted with the aim to evaluate the need and the outcome of percutaneous drainage in treatment of liver abscess and also to assess the parameters during the procedure which will improve the clinical outcome. Methods- prospective observational study conducted in patients with liver abscess who were treated with ultrasound guided percutaneous catheter drainage during the study period. A total of 76 patients were studied. Results- Percutaneous catheter drainage (PCD) had 100% success rate (reduction in abscess volume by atleast 50%) with early clinical improvement and very few complications. Conclusion- Percutaneous catheter drainage of abscess is treatment of choice which is minimally invasive and also has higher success rate with earlier and better clinical and radiological improvement.