Since the early months of the COVID-19 pandemic (March 2020), the COVID-NMA initiative, an international initiative working in conjunction with the World Health Organization (WHO), and led by a team of researchers from Cochrane and other institutions, has been producing relevant, accessible, up-to-date, and trustworthy synthesis of high-quality evidence about the efficacy and safety of interventions for the prevention or treatment of COVID-19, as well as mapping the trial evidence. As part of a broader strategy to disseminate the results of the COVID-NMA initiative more effectively, we will be generating monthly reports summarizing our main findings. Our goal is to present an overview of what is known with moderate or high certainty, highlighting the interventions that appear to be effective or not, to make it easy for researchers and guideline developers to stay up to date with the current evidence on the prevention and treatment of COVID-19. The information in this first edition of the Summary of Main Results report represents the COVID-NMA results up to April 4th, 2022. Given the living nature of this review, though, the most up to date results will be available on covid-nma.com, and any studies pending data extraction are available covid-nma.com.