Gastrointestinal (GI) cancer, which includes a group of tumors, is the most common human cancer. The GI cancers are specifically characterized by high invasive and metastatic potential as well as poor outcome. Both genetic and environmental factors are involved in GC development. Recent epidemiological and clinical investigations have evidenced the relationship between inflammation and development of gastrointestinal cancers. Helicobacter pylori infection is considered to be the leading cause of gastric mucosa inflammation. Present study explored and analyzed the clinical value of combined detection in the blood biochemical investigations in screening of gastric cancer patients in North costal Andhra Pradesh. The conclusions of the present study were significant p-values were obtained for Total protein, creatinine, Blood Urea, CEA, Blood sugar, ALP, SGPT, Albumin, A/G ratio, Globulin, Na and K and insignificant p-value was observed for Bilirubin, SGOT and Cl in study population.