Introduction : the bluish coloration of sclera, frequently, can be associated with multiple systemic syndromes like the ligamentous hyperlaxity, which is a connective tissue disease currentely affecting population, joints, tendons and also some organs, all due to tegumentary weaknesses. Objective : to décrit all epidemiologic and clinical characteristics of joint hypermobility syndrome associated with blue sclera in pediatric patients. Method : a review of the literature was conducted on published articles from May 2002 up to August 2020. Databases checked were Scopus, Wiley Online Library, SciELO, Dialnet, EBSCO, PubMed/Medline. Keywords used were : « blue scleras », « joints », « joint hypermobility syndrome », « connective tissue », all in spanish and english language. A total of 21 bibliographic references were selected. Résultats : the uvea is a highly pigmented tissue, and when this pigmented layer increase or when the sclera decrease, allows the uvea to show through the sclera, giving rise to blue sclera. If extraocular manifestations are obvious, so blue sclera becomes an additional data supporting the diagnosis of joint hypermobility syndrome, may even be the only guide to an exactes diagnosis. Conclusions : it becomes necessary, from an ophthalmologic point of view, consider blue sclera a possible sign of onset aiguë diseases, cause of severe visual loss and systemic syndromes like joint hypermobility syndrome.

Introduction: the bluish coloration of sclera, frequently, can be associated with multiple systemic syndromes like the ligamentous hyperlaxity, which is a connective tissue disease currently affecting population, joints, tendons and also some organs, all due to tegumentary weaknesses. Objective: to describe all epidemiological and clinical characteristics of joint hypermobility syndrome associated with blue sclera in pediatric patients. Method: a review of the literature was conducted on published articles from May 2002 up to August 2020. Databases checked were Scopus, Wiley Online Library, SciELO, Dialnet, EBSCO, PubMed/Medline. Keywords used were: "blue scleras", "joints", "joint hypermobility syndrome", "connective tissue", all in Spanish and English language. A total of 21 bibliographic references were selected. Results: the uvea is a highly pigmented tissue, and when this pigmented layer increases or when the sclera decreases, it allows the uvea to show through the sclera, giving rise to blue sclera. If extraocular manifestations are obvious, so blue sclera becomes an additional data supporting the diagnosis of joint hypermobility syndrome, may even be the only guide to an accurate diagnosis. Conclusions: it becomes necessary, from an ophthalmologic point of view, to consider blue sclera a possible sign of onset acute diseases, cause of severe visual loss and systemic syndromes like joint hypermobility syndrome.

Introduction: the bluish coloration of sclera, frequently, can be associated with multiple systemic syndromes like the ligamentous hyperlaxity, which is a connective tissue disease currentely affecting population, joints, tendons and also some organs, all due to tegumentary weaknesses. Objective: to describe all epidemiologic and clinical characteristics of joint hypermobility syndrome associated with blue sclera in pediatric patients. Method: a review of the literature was conducted on published articles from May 2002 up to August 2020. Databases checked were Scopus, Wiley Online Library, SciELO, Dialnet, EBSCO, PubMed/Medline. Keywords used were: "blue scleras", "joints", "joint hypermobility syndrome", "connective tissue", all in spanish and english language. A total of 21 bibliographic references were selected. Results: the uvea is a highly pigmented tissue, and when this pigmented layer increase or when the sclera decrease, allows the uvea to show through the sclera, giving rise to blue sclera. If extraocular manifestations are obvious, so blue sclera becomes an additional data supporting the diagnosis of joint hypermobility syndrome, may even be the only guide to an accurate diagnosis. Conclusions: it becomes necessary, from an ophthalmologic point of view, consider blue sclera a possible sign of onset acute diseases, cause of severe visual loss and systemic syndromes like joint hypermobility syndrome.

المقدمة: يمكن أن يرتبط اللون المزرق للصلبة، في كثير من الأحيان، بمتلازمات جهازية متعددة مثل فرط الارتخاء الرباطي، وهو مرض في النسيج الضام يؤثر حاليًا على السكان والمفاصل والأوتار وأيضًا بعض الأعضاء، وكل ذلك بسبب نقاط الضعف في الغشاء. الهدف: وصف جميع الخصائص الوبائية والسريرية لمتلازمة فرط الحركة المشتركة المرتبطة بالصلبة الزرقاء لدى مرضى الأطفال. الطريقة: تم إجراء مراجعة للأدبيات على المقالات المنشورة من مايو 2002 حتى أغسطس 2020. كانت قواعد البيانات التي تم فحصها هي Scopus و Wiley Online Library و SciELO و Dialnet و EBSCO و PubMed/Medline. الكلمات المفتاحية المستخدمة هي: "الصلبة الزرقاء"، "المفاصل"، "متلازمة فرط الحركة المشتركة"، "النسيج الضام"، وكلها باللغة الإسبانية والإنجليزية. تم اختيار ما مجموعه 21 مرجعًا ببليوغرافيًا. النتائج: العنبية هي نسيج مصطبغ للغاية، وعندما تزداد هذه الطبقة المصطبغة أو عندما تنخفض الصلبة، فإنها تسمح للعنبية بالظهور من خلال الصلبة، مما يؤدي إلى ظهور الصلبة الزرقاء. إذا كانت المظاهر خارج العين واضحة، لذلك تصبح الصلبة الزرقاء بيانات إضافية تدعم تشخيص متلازمة فرط الحركة المشتركة، قد تكون حتى الدليل الوحيد لتشخيص دقيق. الاستنتاجات: يصبح من الضروري، من وجهة نظر طب العيون، اعتبار الصلبة الزرقاء علامة محتملة على ظهور الأمراض الحادة، وسبب فقدان البصر الشديد والمتلازمات الجهازية مثل متلازمة فرط الحركة المشتركة.