The objective of this study was to assess the impact of COVID-19 on the activities of the Dalal Xel Mental Health Centre in Thies, both in terms of care and revenue. This was a retrospective, descriptive and analytical study of information from the center’s electronic database, comparing patients received during the first wave of covid-19 in Senegal (02 March 2020 to 30 November 2020) with a reference period corresponding to the subsequent year (02 March 2019 to 30 November 2019). There were no significant variations in the sociodemographic characteristics of patients in 2020 with those in 2019 for the same period. For care activities, average decreases of 19%, 52%, and 85% were noted from 02 March 2020 to 30 November 2020 compared to the same period in 2019 for outpatient consultations, outpatient primary care, and hospitalizations respectively. A drop in the center’s revenue was observed from March 2020 onwards, reaching its lowest rate in May 2020 corresponding to 1.7% of the center’s total revenue. This study shows that the current epidemic at COVID-19 has had a strong impact on the care activities and revenue of the Dalal Xel mental health center in Thies. Despite the center’s resilience efforts, effective measures must be taken to avoid the abandonment of care for patients and the proper functioning of the center in a context of limited resources in the mental health field.